In the position of being thoroughly familiar with a subject; conversant_ as, to be at home in a science, In games, the ultimate point to which a player runs, or to which effort is directed; the goal, A dwelling; the residence of a family or household; a seat of domestic life and interests; hence, one's abode; the house in which one has his fixed or usual residence, or which he regards as his definite dwelling-place, intransitive verb_ To move or advance toward a target or goal, To go or return to one's residence or base of operations, adverb_ To the center or heart of something; deeply, On or into the point at which something is directed, adjective_ Of, relating to, or being a place of origin or headquarters, Of, relating to, or being the keys used as base positions for the fingers in touch-typing